Flexible liposomes (FLs) were developed as promising nano-carriers for anticancer drugs.\nCoating them with chitosan (CS) could improve their drug delivery properties. The aim of this study\nwas to investigate the physicochemical characteristics, pharmacokinetics behavior, and cytotoxic\nefficacy of docetaxel (DTX)-loaded CS-coated FLs (C-FLs). DTX-loaded FLs and C-FLs were produced\nvia thin-film evaporation and electrostatic deposition methods, respectively. To explore their\nphysicochemical characterization, the particle size, zeta potential, encapsulation efficiency (EE%),\nmorphology, and DTX release profiles were determined. In addition, pharmacokinetic studies\nwere performed, and cytotoxic effect was assessed using colon cancer cells (HT29). Various FLs,\ndependent on the type of surfactant, were formed with particle sizes in the nano-range, 137.6 Â} 6.3\nto 238.2 Â} 14.2 nm, and an EE% of 59â??94%. Moreover, the zeta potential shifted from a negative to\na positive value for C-FL with increased particle size and EE%, and the in vitro sustained-release\nprofiles of C-FL compared to those of FL were evident. The optimized C-FL containing sodium\ndeoxycholate (NDC) and dicetyl phosphate (DP) elicited enhanced pharmacokinetic parameters and\ncytotoxic efficiency compared to those of the uncoated ones and Onkotaxel®. In conclusion, this\napproach offers a promising solution for DTX delivery.
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